Fancy a bit of magic with your science? This collection dives into the world of fantasy films where human experimentation isn't just about test tubes and lab coats, but also involves spells, mythical creatures, and otherworldly forces. These films blend the eerie with the enchanting, providing a unique perspective on what happens when science meets sorcery. Whether you're a fan of dark fantasy or just looking for something out of the ordinary, this list promises a thrilling journey through realms where the line between human and something else is thrillingly blurred.

Altered States (1980)
Description: A scientist explores altered states of consciousness through sensory deprivation and hallucinogenic drugs, leading to physical transformations.
Fact: The film was based on the novel by Paddy Chayefsky, who also wrote the screenplay under the pseudonym Sidney Aaron.


The Fly (1986)
Description: A scientist's teleportation experiment goes awry, merging his DNA with that of a fly, creating a fantastical horror story about human transformation.
Fact: The film's special effects, particularly the transformation scenes, were groundbreaking at the time and won an Academy Award.


The Cell (2000)
Description: A psychologist enters the mind of a comatose serial killer to find his latest victim, exploring the surreal and fantastical landscape of the human psyche.
Fact: The film's visual effects were heavily inspired by the works of Salvador Dalí and H.R. Giger.


The Prestige (2006)
Description: This film delves into the rivalry between two magicians, one of whom uses a mysterious machine that could be seen as a form of human experimentation, blending science with the supernatural.
Fact: The film was inspired by real-life events involving Nikola Tesla, and the machine in the film was designed to look like Tesla's actual inventions.


The Lazarus Effect (2015)
Description: A group of researchers bring a dead subject back to life, only to find that the experiment has unforeseen, fantastical consequences.
Fact: The film was originally titled "Reawakening" and explores themes of life after death in a modern setting.


The Shape of Water (2017)
Description: While not directly about experiments on humans, it involves a human-like creature subjected to scientific study, blending fantasy with a love story.
Fact: The film won the Academy Award for Best Picture and was directed by Guillermo del Toro, known for his love of fantasy and horror.


Splice (2009)
Description: Scientists create a hybrid creature from human and animal DNA, exploring the ethical boundaries of genetic manipulation in a fantastical setting.
Fact: The creature, Dren, was designed by Guillermo del Toro, who also contributed to the film's visual effects.


The Island of Dr. Moreau (1996)
Description: A shipwrecked man discovers an island where a mad scientist performs experiments to create human-animal hybrids, blending science fiction with fantasy.
Fact: The film was based on H.G. Wells' novel and faced numerous production issues, including director changes.


The Fountain (2006)
Description: This film intertwines three stories across time, one of which involves a scientist experimenting with a tree that holds the secret to eternal life.
Fact: The film was a passion project for Darren Aronofsky, who had been working on the idea for over a decade.


The Imaginarium of Doctor Parnassus (2009)
Description: A fantastical tale where a magician's pact with the Devil leads to experimental journeys into the imagination, exploring human transformation and redemption.
Fact: The film was completed after the death of Heath Ledger, with his role being filled by Johnny Depp, Jude Law, and Colin Farrell.
